Metformin—Acting through Cyclic AMP as well as AMP?

آدنوزین منوفسفات حلقوی ( Cyclic AMP )

Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.

Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia

Apoptotic evasion is a hallmark of cancer. We propose that some cancers may evade cell death by regulating 3'-5'-cyclic adenosine monophosphate (cAMP), which is associated with pro-apoptotic signaling. We hypothesize that leukemic cells possess mechanisms that efflux cAMP from the cytoplasm, thus protecting them from apoptosis. Accordingly, cAMP efflux inhibition should result in: cAMP accumula...

Cyclic AMP as a Second Messenger in Higher Plants'

Adenosine 3':5'-monophosphate, commonly known as cAMP, is a key second messenger in living organisms ranging from Dictyostelium to Homo sapiens. cAMP was first described as a regulator of glycogen breakdown in the liver and is now known to be a second messenger for a wide variety of cellular responses in animals. cAMP is produced from ATP by the action of adenylate cyclase and is hydrolyzed to ...

Secretin induces rapid increases in inositol trisphosphate, cytosolic Ca2+ and diacylglycerol as well as cyclic AMP in rat pancreatic acini.

Previous studies have shown that the dose-response relationship for secretin-stimulated cyclic AMP accumulation is different from that for secretin-stimulated enzyme secretion in the rat exocrine pancreas. Here we show that secretin concentrations of 10(-10) M and higher stimulated a rise in cyclic AMP levels, with maximum effect on cyclic AMP accumulation being achieved already with 10(-8) M-s...